ABSTRACT
Background: Coronavirus disease 2019 (COVID-19) has been associated with significant morbidity and mortality, with cardiovascular involvement being usual. Elevations in cardiac Troponin-I level has proposed as an independent biomarker for mortality among patients with COVID-19. Aim(s): To evaluate the role of high sensivity Troponin-I (hs-TnI) level at hospital admission in predicting 30 day in-hospital mortality and 6-month mortality in patients hospitalized with a COVID-19 diagnosis. Method(s): We performed a retrospective single-center cohort study including consecutive patients aged 18 years and older who were admitted for COVID-19, during a 1-year period (n=818). We excluded patients with acute coronary syndrome (n=23), patients with acute heart failure (n=42), and patients in which hs-TnI level was not dosed at admission (n=163). Patients were divided into two groups according to hs-TnI levels: Hs-TnI <19.8 vs hs-TnI >=19.8 pg/mL. Primary outcomes were 30-day in-hospital mortality and 6-months mortality. According to the data distribution, appropriate statistical tests were conducted to compare independent samples. Multivariable logistic regression was used to analyze mortality risk. Receiver operator characteristics (ROC) curve and area under the curve (AUC) were obtained to determine the discriminative power of hs-TnI as a predictor of mortality. (Figure 1). Result(s): This cohort included 590 patients. Mean age was 71 >=+/-15 years and 52.4% were men. Overall, 209 patients (35.4%) had elevated hs- TnI levels and 381 patients had normal hs-TnI levels. Individuals in the hs-TnI >=19.8 pg/mL group were older (80+/-11 vs 66+/-14 years, p<0.001) and presented higher prevalence of chronic heart failure (24.9% vs 7.1%, p<0.001), hypertension (77.0% vs 57.5%, p<0.001), atrial fibrillation/flutter (19.1% vs 5.5%, p<0.001), prior stroke (12.4% vs 5.2%, p=0.001) and ischemic heart disease (12.4% vs 3.7%, p<0.001). There was no difference in length of hospital stay between the groups (8.0 [IQR 9.6] in hs-TnI 19.8 pg/mL group vs 9.0 [IQR 8.0] normal hs-TnI group, p=0.669). Troponin-I was the only independent predictor of in-hospital mortality (OR 3.80, CI 95%: 2.44-5.93, p<0.001), see Table 1. The troponin levels had the highest area under the receiver operating characteristic curv (AUC) with an AUC of 0.705 (95% CI: 0.667-0.742, p<0.001) for association with the inhospital mortality (figure 1). There was no difference in 6-months mortality between the two groups. Conclusion(s): Acute myocardial injury is common in patients hospitalized with COVID-19. In the present study a TnI level >=19.8 pg/mL was predictor of 30 days in-hospital mortality, suggesting that raised levels of this biomarker is associated with adverse prognosis. This tool might be useful for COVID-19 patient risk stratification. Further studies are needed to provide robust data and reliable recommendations on this theme.
ABSTRACT
The pandemic caused by SARS-CoV-2 brought to society a health crisis that drastically affected the global economy and brought more restrictive measures to food supply establishments, which are classified as essential activities. However, they had to adapt to the new hygienic-sanitary operating protocol, established through regulations published by the Federal and State Governments in order to reduce the chances of viral spread. The objective of the study was to evaluate the hygienic and sanitary conditions of fish sold in fish markets in the city of Nova Iguacu/RJ, through questionnaires on the application of good marketing and handling practices, during the lockdown related to the coronavirus pandemic. An observational "checklist" type questionnaire was used to assess the hygienic and sanitary conditions of fish in 13 fish markets located in 7 districts of Nova Iguacu/RJ. It was observed that in 92% of the establishments visited had materials and equipment in disuse in the outdoor area, had failures in conservation, sanitation and adequate maintenance, without vector and pest control, without a suitable container for waste collection, lack of personal cleanliness and did not present the amount of flaky ice adequate to coat the fish. Thus, it was possible to check that the establishments did not follow the basic rules of hygiene and safety of the fish to reduce the dissemination of the coronavirus, confirming that the commercialization of fish in the fish markets visited in the municipality of Nova Iguacu/RJ does not meet the recommended standards of hygiene and packaging of the products sold. Therefore, the relevance of this study is to provide fishmongers in the municipality of Nova Iguacu, practical and viable guidelines for adapting to the legislation, with the main objective of updating and favoring the reinforcement of Good Handling Practices through an illustrative folder distributed later on visits to establishments.